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Quantifying the effects of quadrupolar sinksvia15N relaxation dynamics in metronidazoles hyperpolarizedviaSABRE-SHEATH
- Source :
- Chemical Communications. 56:9098-9101
- Publication Year :
- 2020
- Publisher :
- Royal Society of Chemistry (RSC), 2020.
-
Abstract
- 15N spin-lattice relaxation dynamics in metronidazole-15N3 and metronidazole-15N2 isotopologues are studied for rational design of 15N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. 15N relaxation dynamics mapping reveals the deleterious effects of interactions with the polarization transfer catalyst and a quadrupolar 14N nucleus within the spin-relayed 15N-15N network.
- Subjects :
- chemistry.chemical_classification
Materials science
Biomolecule
Metals and Alloys
General Chemistry
Polarization (waves)
Catalysis
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
medicine.anatomical_structure
chemistry
Chemical physics
Materials Chemistry
Ceramics and Composites
medicine
Isotopologue
Nucleus
Signal amplification
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi...........8c41933b0bcaa1890b7b0077d8a4e9d5
- Full Text :
- https://doi.org/10.1039/d0cc03994b