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Synthesis, Radiolabeling, and Biological Evaluation of the trans-Stereoisomers of 1-Amino-3-(fluoro-18F)-4-fluorocyclopentane-1-carboxylic Acid as PET Imaging Agents

Authors :
Weiping Yu
Mark M. Goodman
Jonathon A. Nye
Ronald J. Voll
John Bacsa
Zhaobin Zhang
Thomas C. Pickel
Gouthami Pashikanti
Lanny S. Liebeskind
Jeffrey J. Olson
Source :
ACS Pharmacology & Translational Science. 4:1195-1203
Publication Year :
2021
Publisher :
American Chemical Society (ACS), 2021.

Abstract

The enantiomeric non-natural cyclic amino acids (3R,4R)-1-amino-3-fluoro-4-(fluoro-18F)cyclopentane-1-carboxylic acid and (3S,4S)-1-amino-3-fluoro-4-(fluoro-18F)cyclopentane-1-carboxylic acid ([18F...

Details

ISSN :
25759108
Volume :
4
Database :
OpenAIRE
Journal :
ACS Pharmacology & Translational Science
Accession number :
edsair.doi...........8c611906e6f77d67a492a97bbec0d6a4
Full Text :
https://doi.org/10.1021/acsptsci.1c00062