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Synthesis and Hydrolysis of Thiol Derivatives of Molybdocene Dichloride Incorporating Electron-Withdrawing Substituents
- Source :
- Organometallics. 25:3417-3421
- Publication Year :
- 2006
- Publisher :
- American Chemical Society (ACS), 2006.
-
Abstract
- Hydrolysis studies of derivatives of molybdocene dichloride in which the two chloride ligands were replaced by 3,5-bis(trifluoromethyl)thiophenol, 3,5-bis(trifluoromethyl)benzyl thiol, and 2,2,2-trifluoroethane thiol ligands confirmed that the electron-withdrawing groups affect the lability of the Mo−S bonds and promote slow generation of the putative biologically active species “Cp2Mo2+”; the trifluoroethane thiol derivative underwent 50% hydrolysis in 14 h in 10% D2O/DMSO-d6. The structure of molybdocene bis(S-3,5-bis(trifluoromethyl)benzyl thiol) was confirmed by X-ray crystal structure analysis.
- Subjects :
- chemistry.chemical_classification
Trifluoromethyl
Chemistry
Thiophenol
Organic Chemistry
Trifluoroethane
Crystal structure
Medicinal chemistry
Chloride
Inorganic Chemistry
chemistry.chemical_compound
Hydrolysis
medicine
Thiol
Polar effect
Organic chemistry
Physical and Theoretical Chemistry
medicine.drug
Subjects
Details
- ISSN :
- 15206041 and 02767333
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Organometallics
- Accession number :
- edsair.doi...........8c8f23c011bd6f79c40b97b8d4c33a6e