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Bolus ornithine and arginine-ketoglutarate supplementation in distal intestine after 65% resection in rats
- Source :
- Nutrition Research. 20:1807-1816
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- Introduction: Enteral feeding has been reported to increase intestinal mucosa proliferation after resection. Dietary components influence the intestinal adaptive response. The purpose of this study was to evaluate the effect of ornithine- (OKG) or arginine-ketoglutarate (AKG) bolus supplementation on intestinal postresectional adaptation in the rat. Methods: Male Wistar rats underwent 65% small-bowel resection and received either OKG 3 g/kg/day, isonitrogenous AKG or saline by gavage once daily. The animals had free access to rat chow. Sampling was done 10 days after resection. Fed animals without surgery or specific treatment served as controls. Results: Mucosal wet weight, DNA, RNA, protein content and sucrose activity of the mucosa, as well as villus height were significantly increased in all resected animals compared to controls. No significant differences in body weight or intestinal adaptation could be found between the three dietary groups. Conclusion: Postoperative enteral bolus feeding supplemented with OKG or AKG did not significantly enhance the adaptation of the remnant small bowel 10 days after massive intestinal resection when rats had free access to rat chow. © 2000 Elsevier Science Inc.
- Subjects :
- medicine.medical_specialty
Nutrition and Dietetics
Arginine
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Ornithine
Biology
Short bowel syndrome
medicine.disease
Enteral administration
Gastroenterology
Small intestine
chemistry.chemical_compound
Endocrinology
medicine.anatomical_structure
Bolus (medicine)
chemistry
Intestinal mucosa
Internal medicine
medicine
Saline
Subjects
Details
- ISSN :
- 02715317
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Nutrition Research
- Accession number :
- edsair.doi...........8c90c2c9afd43d6c0663b6e2962554bf