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VNN disease and status of breeding for resistance to NNV in aquaculture
- Source :
- Aquaculture and Fisheries. 7:147-157
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Viral nervous necrosis (VNN) disease, caused by the nervous necrosis virus (NNV), is a devastating disease, leading to high mortality rate and huge economical loss in aquaculture. In the past 30 years, many studies on the virus, host responses to the virus infection and diagnostics have yielded a lot of knowledge on developing measures to prevent the VNN disease. Although genetic improvement of disease resistance through breeding is inheritable and has long-lasting positive effect on aquaculture, it is a very challenging task in conventional selective breeding for improving disease resistance. With the advances in mapping quantitative trait loci (QTL) and genome wide association studies (GWAS) for NNV resistance in aquaculture species, DNA markers and genes associated with NNV resistance have been identified, making the application of marker-assisted selection (MAS) and genomic selection (GS) for NNV resistance possible. A few genes for NNV resistance are identified and are being used for genome editing to rapidly improve NNV resistance. In this review, we present the current knowledge on the NNV, host responses to NNV infection, diagnostic methods and vaccines available for NNV disease. In addition, we summarize the current status of conventional and molecular breeding for NNV resistance and highlight future directions, including genome editing for improving NNV resistance in aquaculture.
- Subjects :
- Molecular breeding
Genetics
0303 health sciences
Ecology
Genome-wide association study
04 agricultural and veterinary sciences
Disease
Aquatic Science
Plant disease resistance
Biology
Quantitative trait locus
Selective breeding
Virus
03 medical and health sciences
Genome editing
040102 fisheries
0401 agriculture, forestry, and fisheries
Ecology, Evolution, Behavior and Systematics
030304 developmental biology
Subjects
Details
- ISSN :
- 2468550X
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Aquaculture and Fisheries
- Accession number :
- edsair.doi...........8c9f6e6a4a276f37165ed338e631e9b9