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Communication—Microfluidic Electrochemical Acetylcholine Detection in the Presence of Chlorpyrifos
- Source :
- Journal of The Electrochemical Society. 166:G178-G181
- Publication Year :
- 2019
- Publisher :
- The Electrochemical Society, 2019.
-
Abstract
- An amperometric acetylcholine sensor was developed for use in a microfluidic system and characterized with chlorpyrifos and its metabolite, chlorpyrifos oxon. This enzymatic sensor was highly selective for acetylcholine, with a detection limit of 0.2 μM and sensitivity of 1.7 nA μM−1 from 1–150 μM. Though chlorpyrifos had no effect on sensor function, chlorpyrifos oxon significantly inhibited response across a range of concentrations (0.5–50 μM). Inhibition was reversed by 2-pyridine aldoxime methyl chloride. This platform can be used to both quantify acetylcholine in the presence of chlorpyrifos and as a biorecognition method for chlorpyrifos oxon.
- Subjects :
- Chromatography
Renewable Energy, Sustainability and the Environment
Chemistry
Microfluidics
Condensed Matter Physics
Electrochemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry.chemical_compound
Chlorpyrifos
Materials Chemistry
medicine
Acetylcholine
medicine.drug
Subjects
Details
- ISSN :
- 19457111 and 00134651
- Volume :
- 166
- Database :
- OpenAIRE
- Journal :
- Journal of The Electrochemical Society
- Accession number :
- edsair.doi...........8e08a150163f3443558e36cee15f76d2