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Water-soluble phenolic compounds and their anti-HIV-1 activities from the leaves of Cyclocarya paliurus
- Source :
- Journal of Food and Drug Analysis. 18
- Publication Year :
- 2020
- Publisher :
- The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA), 2020.
-
Abstract
- Eight phenolic compounds including five glucuronides were isolated from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja, which is used as a source of tea. Their structures were characterized by spectroscopic methods. The results of biological assay showed that compounds 1 and 5 had good activities against HIV-1 induced cytopathic effects in C8166 lymphocyte at non-cytotoxic concentrations, with EC50 values of 31.74 and 10.76 μM, and therapeutic index (TI) values of >13.02 and 25.46, respectively. Relationship between molecular structures and their bioactivities was discussed.
- Subjects :
- Pharmacology
0303 health sciences
biology
Traditional medicine
030309 nutrition & dietetics
Stereochemistry
Chemistry
Lymphocyte
Chemical structure
010401 analytical chemistry
Juglandaceae
biology.organism_classification
01 natural sciences
0104 chemical sciences
03 medical and health sciences
medicine.anatomical_structure
Paliurus
Therapeutic index
medicine
Bioassay
Cyclocarya
Food Science
EC50
Subjects
Details
- ISSN :
- 22246614
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Food and Drug Analysis
- Accession number :
- edsair.doi...........8e3738bf5f8fdcf8b9495798281911e1