Putative Anti-Cancer Action of Aloe vera Via Butyrate Fermentation

The efficacy of Aloe vera has been known for various health and disease-related conditions. Butyrate, a well-known epigenetic histone deacetylase inhibitor, is causally implicated in tumorigenesis and tumor angiogenesis. Butyrate was shown to induce cell cycle arrest, differentiation, and apoptosis in a variety of cancer cells. Dietary factors, microbiota composition, and microbiota metabolism are intimately intertwined in a complex network, highlighting the importance of intestinal functions for health maintenance. In the present review, we discuss aloe vera fermentation as a tumor-suppressive process generating microbial-derived butyrate.