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A novel colorimetric and ratiometric fluorescent Cu2+ sensor based on hydrazone bearing 1,8-naphthalimide and pyrrole moieties
- Source :
- Sensors and Actuators B: Chemical. 251:813-820
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- A 1,8-naphthalimide hydrazone derivative bearing a pyrrole unit is a highly selective ratiometric fluorescent Cu 2+ probe used to monitor intracellular Cu 2+ in HeLa cells. This probe functions via a unique hydrolysis mechanism through Cu 2+ -promoted electrophilic substitution. Binding is confirmed through UV–vis absorption, fluorescence measurements, mass spectroscopy, IR, X-ray single crystal diffraction, and DFT calculation.
- Subjects :
- chemistry.chemical_classification
010405 organic chemistry
Chemistry
Metals and Alloys
Hydrazone
010402 general chemistry
Condensed Matter Physics
Photochemistry
Mass spectrometry
01 natural sciences
Fluorescence
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Hydrolysis
chemistry.chemical_compound
Electrophilic substitution
Materials Chemistry
Electrical and Electronic Engineering
Absorption (chemistry)
Instrumentation
Derivative (chemistry)
Pyrrole
Subjects
Details
- ISSN :
- 09254005
- Volume :
- 251
- Database :
- OpenAIRE
- Journal :
- Sensors and Actuators B: Chemical
- Accession number :
- edsair.doi...........8ed6a32e39fc1af98a5db17bacb55261