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Tandem reaction of heterocyclic ketene aminals with diazoesters: Synthesis of pyrimidopyrrolidone derivatives
- Source :
- Tetrahedron Letters. 60:151136
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- A tandem reaction of heterocyclic ketene aminals (HKAs) with diazoesters in the presence of a Cu catalyst is demonstrated for the efficient synthesis of pyrimidopyrrolidone derivatives. The reaction shows a broad substrate scope and excellent functional group tolerance. Our method provides rapid access to diverse pyrimidopyrrolidones in moderate to excellent yields under mild reaction conditions.
- Subjects :
- Reaction conditions
010405 organic chemistry
education
Organic Chemistry
Ketene
Substrate (chemistry)
010402 general chemistry
01 natural sciences
Biochemistry
Combinatorial chemistry
humanities
0104 chemical sciences
Catalysis
chemistry.chemical_compound
chemistry
Cascade reaction
Drug Discovery
Functional group
Rapid access
Subjects
Details
- ISSN :
- 00404039
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........8fba0774fc2acb7951d00d4ba4323045