ChemInform Abstract: Malic Acid: A Convenient Precursor for the Synthesis of Peptide Secondary Structure Mimetics

Authors :: Chris Lum
Min S. Lee
Hwa-Ok Kim
Source :: ChemInform. 28
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: Syntheses of optically active ether-linked β-lactams and aza-proline analogues via 4-bromo-2-hydroxybutanoic acid esters derived from (S)- or (R)-malic acid are described. From these intermediates peptide secondary structure mimetics can be synthesized.

Subjects :: chemistry.chemical_classification
chemistry.chemical_compound
chemistry
fungi
food and beverages
Peptide
General Medicine
Malic acid
Optically active
Combinatorial chemistry
Protein secondary structure
Amino acid

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