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Significance of synaptic Zn 2+ signaling in zincergic and non-zincergic synapses in the hippocampus in cognition
- Source :
- Journal of Trace Elements in Medicine and Biology. 38:93-98
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- A portion of zinc concentrates in the synaptic vesicles in the brain and is released from glutamatergic (zincergic) neuron terminals. It serves as a signaling factor (in a form of free Zn2+). Both extracellular Zn2+ signaling, which predominantly originates in Zn2+ release from zincergic neuron terminals, and intracellular Zn2+ signaling, which is often linked to extracellular Zn2+ signaling, are involved in hippocampus-dependent memory. At mossy fiber-CA3 pyramidal cell synapses and Schaffer collateral-CA1 pyramidal cell synapses, which are zincergic, extracellular Zn2+ signaling leads to intracellular Zn2+ signaling and is involved in learning and memory. At medial perforant pathway-dentate granule cell synapses, which are non-zincergic, intracellular Zn2+ signaling, which originates in the internal stores containing Zn2+, is involved in learning and memory. The blockade of Zn2+ signaling with Zn2+ chelators induces memory deficit, while the optimal amount range of Zn2+ signaling is unknown. It is possible that the degree and frequency of Zn2+ signaling, which determine the increased Zn2+ levels, modulates learning and memory as well as intracellular Ca2+ signaling. To understand the precise role of synaptic Zn2+ signaling in the hippocampus, the present paper summarizes the current knowledge on Zn2+ signaling at zincergic and non-zincergic synapses in the hippocampus in cognition and involvement of zinc transporters and zinc-binding proteins in synaptic Zn2+ signaling.
- Subjects :
- inorganic chemicals
0301 basic medicine
Mossy fiber (hippocampus)
Hippocampus
Biology
Biochemistry
Synaptic vesicle
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
medicine
Anatomy
Granule cell
enzymes and coenzymes (carbohydrates)
030104 developmental biology
medicine.anatomical_structure
Schaffer collateral
biological sciences
health occupations
bacteria
Molecular Medicine
Neuron
Pyramidal cell
Signal transduction
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 0946672X
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Journal of Trace Elements in Medicine and Biology
- Accession number :
- edsair.doi...........9072d3a2daccad3c21c50040b9dc5631