Cardiac Haemodynamics with Nebivolol and Metoprolol in Patients with Essential Hypertension

As part of a multicentre double-blind comparative study of the effects of metoprolol and nebivolol in patients with hypertension in Czechoslovakia, systolic time intervals (STIs) were used to evaluate the effects of these drugs after 3 months. Examination of STIs was performed in 29 subjects with essential hypertension before and after 1, 2 and 3 months’ treatment with either metoprolol 100mg twice daily or nebivolol 5mg once daily.