THE CARDIAC MYOSIN ACTIVATOR, OMECAMTIV MECARBIL, IMPROVES LEFT VENTRICULAR MYOCARDIAL DEFORMATION IN CHRONIC HEART FAILURE (COSMIC-HF)

Background: Omecamtiv mecarbil (OM) is a selective cardiac myosin activator shown to improve measures of LV structure and function. We assessed the effect of OM on myocardial strain (deformation). Methods: In the COSMIC-HF trial, 448 patients with chronic, symptomatic heart failure (HF) and left