ChemInform Abstract: 1,4-Benzothiazine-2-carboxylic Acid 1-Oxides as Analogues of Antibacterial Quinolones

The synthesis of 1,4-benzothiazine-2-carboxylic acid 1-oxides as agents which mimic quinolone antibacterial, are described. The key step includes intramolecular cyclization of phenylsulfinyl acrylates 17 and 18 which are prepared in six steps from 11. None of new target compounds showed interesting antibacterial activity in vitro against the tested strains.