Copolymer based radiotracers for liver ASGP-R targeted SPECT imaging

Asialoglycoprotein receptor (ASGP-R) is a well-known cell surface receptor specific for liver, present in normal mammalian hepatocyte membrane. Detection of its number and activity is an excellent method for evaluating the status and function of liver [1]. Copolymer based radiotracers with controllable ratio of targeting moiety (VLA) were developed as potential ASGP-R targeted imaging agents. P(VLA-co-VNI) were synthesized by free-radical copolymerization and lyophilized for Tc instant kit labeling with high yield and RCP (N99%) [2]. Static 3D SPECT/CT images were acquired at 1 h and 4 h after injection of 18 MBq series of Tc-tracers in normalmice. The results showed that liver has specific high uptake at 1 h p.i. with good retention. (NSFC (21271030) and 973 Program of China (2014CB744503)).