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Multimodal MRI Segmentation of Brain Tissue and T2-Hyperintense White Matter Lesions in Multiple Sclerosis using Deep Convolutional Neural Networks and a Large Multi-center Image Database
- Source :
- 2018 9th Cairo International Biomedical Engineering Conference (CIBEC).
- Publication Year :
- 2018
- Publisher :
- IEEE, 2018.
-
Abstract
- Multiple sclerosis (MS) is a demyelinating disease that affects the central nervous system (CNS) and is characterized by the presence of CNS lesions. Volumetric measures of tissues, including lesions, on magnetic resonance imaging (MRI) play key roles in the clinical management and treatment evaluation of MS patient. Recent advances in deep learning (DL) show promising results for automated medical image segmentation. In this work, we used deep convolutional neural networks (CNNs) for brain tissue classification on MRI acquired from MS patients in a large multi-center clinical trial. Multi-channel MRI data that included T1-weighted, dual-echo fast spin echo, and fluid-attenuated inversion recovery images were acquired on these patients. The pre-processed images (following co-registration, skull stripping, bias field correction, intensity normalization, and de-noising) served as the input to the CNN for tissue classification. The network was trained using expert-validated segmentation. Quantitative assessment showed high Dice similarity coefficients between the CNN and the validated segmentation, with DSC values of 0.94 for white matter and grey matter, 0.97 for cerebrospinal fluid, and 0.85 for T2 hyperintense lesions. These results suggest that deep neural networks can successfully segment brain tissues, which is crucial for reliable assessment of tissue volumes in MS.
- Subjects :
- medicine.diagnostic_test
business.industry
Deep learning
Pattern recognition
Magnetic resonance imaging
Image segmentation
Grey matter
Convolutional neural network
Hyperintensity
030218 nuclear medicine & medical imaging
White matter
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
medicine
Segmentation
Artificial intelligence
business
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- 2018 9th Cairo International Biomedical Engineering Conference (CIBEC)
- Accession number :
- edsair.doi...........9221ca776ea52cedc3ef3700a0d824b4