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Electrophilic addition to the multiple bond of 1-carboxymethyl-5-fluorouracil
- Source :
- Russian Chemical Bulletin. 69:114-117
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- 1-Carboxymethyl-5-fluoro-5-halogeno-6-hydroxy-5,6-dihydrouracils and 1-carboxymethyl- 5-fluoro-6-hydroxy-5-nitro-5,6-dihydrouracil were synthesized in high yields by oxidative halogenation or nitration of 1-carboxymethyl-5-fluorouracil. Oxidative halogenation or nitration of 5-fluoro-1-(methoxycarbonylmethyl)uracil in acidic media results in the addition of the corresponding groups at the C(5) atom of uracil and simultaneous hydrolysis of the ester group. Bimolecular ions of the obtained compounds were detected in the negative ion mass spectra.
- Subjects :
- inorganic chemicals
010405 organic chemistry
Electrophilic addition
Halogenation
Uracil
macromolecular substances
General Chemistry
Oxidative phosphorylation
010402 general chemistry
01 natural sciences
Medicinal chemistry
0104 chemical sciences
Ion
Hydrolysis
chemistry.chemical_compound
chemistry
Nitration
Mass spectrum
heterocyclic compounds
Subjects
Details
- ISSN :
- 15739171 and 10665285
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Russian Chemical Bulletin
- Accession number :
- edsair.doi...........92b08a44077f766302ed56401be1c089