Brief communication: Effect of nomadic subsistence practices on lactase persistence associated genetic variation in Kuwait

Lactase persistence (LP)—the ability to digest lactose in adulthood—is paradigmatic of Holo- cenic dietary change affecting the evolutionary trajec- tory of specific populations. Kuwait represents one location of high LP where the variation in associated genomic regions has not been examined. Here, we pres- ent new sequence data from a 427 bp amplicon 14 kb upstream of the LCT (lactase) gene for two Bedouin tribal populations, the Ajman and Mutran. We estimate the frequency of known LP associated alleles and dis- cuss the impact of nomadic-pastoralism on the associated genetic variation. We observe high frequency (56% on average) of the 213,915*G allele in both tribes, which is consistent with the high prevalence of LP in Kuwait. Whilst LP associated alleles occur in Kuwait at a similar frequency to other regional popula- tions, we suggest that the 213,915*G allele frequency among the Kuwaiti Bedouin may be higher than among non-Bedouin Kuwaitis, possibly due to greater histori- cal reliance on milk consumption or genetic drift. Am J Phys Anthropol 152:140-144, 2013. V C 2013 Wiley Periodi