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Oxidation of Protopine at a Pyrolytic Graphite Electrode Using Cyclic and Square-Wave Voltammetry

Authors :
Eva Vrublova
Jitka Ulrichová
Miroslav Fojta
Jan Vacek
Vilím Šimánek
Source :
Electroanalysis. 22:2879-2883
Publication Year :
2010
Publisher :
Wiley, 2010.

Abstract

This paper describes oxidation of the isoquinoline alkaloid, protopine (PR) at a pyrolytic graphite electrode (PGE) using cyclic and square-wave voltammetry. In the alkaline range (pH 7.5–10.5) of a Britton–Robinson (B–R) buffer, a PR oxidation can be observed as a well-developed voltammetric peak around + 0.9 V (vs. Ag j AgCl j 3 M KCl). With increasing pH of the B–R buffer, the PR peak is shifted to less positive potentials. The acquired voltammetric data suggest that PR strongly adsorbs onto the surface of the pyrolytic graphite where it is subjected to irreversible electrochemical oxidation in its uncharged free (tricyclic) base form. The results are discussed in connection with the electrochemical oxidation of other isoquinoline alkaloids and the potential applications of these data.

Details

ISSN :
10400397
Volume :
22
Database :
OpenAIRE
Journal :
Electroanalysis
Accession number :
edsair.doi...........93d71418ba07b6ec6068504ae2441d20
Full Text :
https://doi.org/10.1002/elan.201000353