ALTERATIONS IN SIGNAL TRANSDUCTION AND INTRACELLULAR SIGNALING PROCESSES DURING SIMULATED MICROGRAVITY

A modified NASA validated tail suspension animal model of simulated microgravity was used to induce weightlessness in mice. Animals were suspended by tail to simulate microgravity for 21 days. Effect of simulated microgravity on the expression G‐proteins was studied in various tissues. Specific antibodies were used to probe stimulatory and inhibitory G‐proteins on Western Blots. Our results suggested that there is a significant increase in the amounts G‐protein subunits in hind limb suspended tissues compared to controls. Further experiments are required to establish any relationship in the apparent changes in G‐proteins and inositol phosphates.