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A histopathological score on baseline biopsies from elderly donors predicts outcome 1 year after renal transplantation
- Source :
- APMIS. 120:182-186
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- Toft BG, Federspiel BH, Sorensen SS, Bagi P, Nielsen HB, Andersen CB. A histopathological score on baseline biopsies from elderly donors predicts outcome 1 year after renal transplantation. APMIS 2012; 120: 182–6. Kidneys from elderly deceased patients and otherwise marginal donors may be considered for transplantation and a pretransplantation histopathological score for prediction of postoperative outcome is warranted. In a retrospective design, 29 baseline renal needle biopsies from elderly deceased donors (age: 63 ± 4 years; mean ± SD) were evaluated independently by three pathologists and with ten or more glomeruli and one artery present the biopsy was histopathologically scored (numeric score: 0–12) according to the presence of glomerulosclerosis, tubular atrophy, interstitial fibrosis and increased wall thickness of arteries and/or arterioles. Nineteen renal baseline biopsies from 15 donors (age: 64 ± 10 years) were included and following consensus the histopathological score was 4.3 ± 2.1 (intraclass correlation coefficient: 0.81; confidence interval: 0.66–0.92). The donor organs were used for single renal transplantation (recipient age: 47 ± 3 years). Two grafts were lost after the transplantation. In the remaining 17 recipients the 1-year creatinine clearance (54 ± 6 mL/min) correlated to the baseline histopathological score (r2 = 0.59; p
- Subjects :
- Microbiology (medical)
medicine.medical_specialty
medicine.diagnostic_test
Intraclass correlation
business.industry
Urology
Glomerulosclerosis
Renal function
General Medicine
medicine.disease
Graft function
Confidence interval
Pathology and Forensic Medicine
Surgery
Transplantation
medicine.anatomical_structure
Biopsy
medicine
Immunology and Allergy
business
Artery
Subjects
Details
- ISSN :
- 09034641
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- APMIS
- Accession number :
- edsair.doi...........944df63c40beea1e94eceaaa09999ce6
- Full Text :
- https://doi.org/10.1111/j.1600-0463.2011.02824.x