Synthesis and Antifungal Activity of Khusinol and its Derivatives

Khusinol isolated from vetiver oil was subjected to various chemical modifications. Ester derivatives of khusinol were prepared with acetic anhydride and benzoyl chloride. Epoxides of khusinol were synthesized using perbenzoic acid, vanadium oxyacetylacetonate–t-butyl hydroperoxide, and N-bromosuccinimide– sodium hydroxide. All the compounds showed promising in vitro antifungal potential against Alternaria triticina, Drechslera oryzae, and Fusarium moniliforme with ED50 values in the range of 200–250 μg/mL.