A Timeless Tale: G4 structure recognition by the fork protection complex triggers unwinding by <scp>DDX</scp> 11 helicase

Authors :: Catherine H. Freudenreich
Source :: The EMBO Journal. 39
Publication Year :: 2020
Publisher :: EMBO, 2020.
Abstract: How the replisome senses and deals with DNA secondary structures has been a mystery. A new study from the Sale and Pellegrini laboratories finds that the Timeless protein has a G-quadruplex binding domain that works together with the DDX11 helicase to facilitate replication of G4 DNA structures.

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