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Synergy of CO2 Response and Aggregation-Induced Emission in a Block Copolymer: A Facile Way To 'See' Cancer Cells
- Source :
- ACS Applied Materials & Interfaces. 11:37077-37083
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- Carbon dioxide (CO2), an important gas molecule metabolite produced by the tricarboxylic acid cycle, is a direct signal for identifying cancers in cells and tissues. Herein, design and synthesis of a novel "breathable" block polymer supramolecular assembly probe consisting of a hydrophilic block, an amidine-containing CO2-responsive block, and an aggregation-induced emission (AIE) luminescence block to detect CO2 metabolized by cancer cells is reported. The triblock copolymer poly-(4-undecoxy tetraphenyl ethylene methacrylate)-b-poly-((N-amidino)-(2,3-dihydro-1H-1, 4-methyl-1, 2,3-triazole)-(ethenylbenzene))-b-poly(ethylene oxide) (PTPE-b-PAD-b-PEO) was successfully synthesized and characterized. This triblock copolymer could be self-assembled into "breathable" aqueous solution vesicles. In the presence of CO2, the amidine-containing CO2-responsive block (PAD block) of the vesicle "inhales" an amount of CO2, which causes the volume of the vesicle to expand. The expansion of the vesicle induces the aggregation of the AIE luminescence block (PTPE block), which resulted in the fluorescence intensity enhancement. The supramolecular vesicles "exhale" CO2, and the volume and AIE phenomenon of the vesicles decrease when N2 is passed into the solution. On the basis of this reversible change of fluorescence intensity, HeLa cervical cancer cells, CNE1 nasopharynx cancer cells, 5-8F nasopharynx cancer cells, 16HBE human bronchial epithelial cells, and GES-1 human gastric mucosa epithelial cells have all been successfully detected and identified.
- Subjects :
- Materials science
Ethylene oxide
biology
Vesicle
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
Methacrylate
biology.organism_classification
01 natural sciences
0104 chemical sciences
Supramolecular assembly
HeLa
chemistry.chemical_compound
chemistry
Cancer cell
Biophysics
Copolymer
General Materials Science
0210 nano-technology
Luminescence
Subjects
Details
- ISSN :
- 19448252 and 19448244
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- ACS Applied Materials & Interfaces
- Accession number :
- edsair.doi...........95aa0b3cc51b5ae3e69c45cd740f09d3