Synthesis and biological activity of cyclohexylamine derivatives

2-(p-hydroxyphenyl)cyclohexylamides were synthesized from ω-chlorocarboxylic acids using the Ritter reaction. Subsequent reduction under the action of LiAlH4 led to the corresponding substituted cyclic amines. The acute toxicity, analgesic properties, and antidepressant activity of the synthesized compounds were studied and their action on locomotion and exploration activity in the open-field test was evaluated.