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PD-1 expression on CD8+ T cells regulates their differentiation within lung allografts and is critical for tolerance induction
- Source :
- American Journal of Transplantation. 18:216-225
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Immunological requirements for rejection and tolerance induction differ between various organs. While memory CD8+ T cells are considered a barrier to immunosuppression-mediated acceptance of most tissues and organs, tolerance induction after lung transplantation is critically dependent on central memory CD8+ T lymphocytes. Here we demonstrate that costimulation blockade-mediated tolerance after lung transplantation is dependent on programmed cell death 1 (PD-1) expression on CD8+ T cells. In the absence of PD-1 expression, CD8+ T cells form prolonged interactions with graft-infiltrating CD11c+ cells; their differentiation is skewed towards an effector memory phenotype and grafts are rejected acutely. These findings extend the notion that requirements for tolerance induction after lung transplantation differ from other organs. Thus, immunosuppressive strategies for lung transplant recipients need to be tailored based on the unique immunological properties of this organ.
- Subjects :
- Transplantation
Lung
Effector
medicine.medical_treatment
CD11c
030230 surgery
Biology
Phenotype
03 medical and health sciences
Tolerance induction
0302 clinical medicine
medicine.anatomical_structure
Immunology
medicine
Immunology and Allergy
Cytotoxic T cell
Lung transplantation
Pharmacology (medical)
CD8
030215 immunology
Subjects
Details
- ISSN :
- 16006135
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- American Journal of Transplantation
- Accession number :
- edsair.doi...........965dda178ee94ebb30387c5ba612ce55