Assessment of the character of relationship between oxidative stress indicators and the level of individual proinflammatory cytokines in patients with rosacea

Objective – to evaluate the relationship between oxidative stress indicators and individual proinflammatory cytokine levels in patients with rosacea.Material and methods. We examined 64 patients with rosacea (49 women, 15 men) aged from 28 to 63 years, of whom 23 were diagnosed with erythematous-telangiectatic and 41 persons with papulopustular rosacea. In patients with rosacea, indicators of oxidative stress were determined -the content of malonic aldehyde in erythrocytes and blood plasma, and fractions of oxidatively modified proteins (OMP Е370, OMP Е430) in blood serum, and the serum content of individual pro-inflammatory cytokines - interleukin-8 (IL-8) and interleukin-18 (IL-18) by enzyme immunoassay. To assess the nature of the relationship between the studied indicators, the methods of correlation analysis were used.Results. In patients with rosacea, there was a significant increase in the content of MA in plasma and erythrocytes compared to the control group (respectively: by 51.4% and 17.3%, p