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Impact of caffeine ingestion on dipyridamole myocardial perfusion gated SPECT study

Authors :
Suna Kirac
Mustafa Serteser
Yalin Tolga Yaylali
Doğangün Yüksel
Beyza Akdag
Olga Yaylali
Source :
Journal of Indian College of Cardiology. 3:111-119
Publication Year :
2013
Publisher :
Medknow, 2013.

Abstract

Introduction Dipyridamole is increasingly used for vasodilatation stress test. Caffeine diminishes its effect. At present, there is still no consensus as to whether and how long caffeine should be interrupted. We hypothesized that caffeine impacts the dypyridamole gated MPS findings in patients with coronary artery disease. Methods Thirty-six patients who had >50% stenosis in at least one vessel on coronary angiography (CAG) were included in our study. Gated MPS with standard dipyridamole stress test was used to assess myocardial perfusion defects and LVEF values before and after caffeine ingestion. Myocardial perfusion images and gated analyses were assessed visually and quantitatively. The results were analyzed by the t test for paired observations. Results The mean serum caffeine levels were significantly higher 1 h after caffeine ingestion (1.10 ± 0.05 mg/L vs. 5.82 ± 1.80 mg/L) (p Conclusions We demonstrated that caffeine may cause attenuation of extent and severity of myocardial perfusion abnormalities during dipyridamole stress gated MPS study. Thus, patients should refrain from caffeine at least 1 day before the test.

Details

ISSN :
15618811
Volume :
3
Database :
OpenAIRE
Journal :
Journal of Indian College of Cardiology
Accession number :
edsair.doi...........971dcd66dbc37b10a80b18174c2e2e93
Full Text :
https://doi.org/10.1016/j.jicc.2013.05.007