A-20 Frailty Is Associated with Decreased Social–Emotional Functioning in People with HIV: A National Institutes of Health Toolbox Emotion Battery Study

Objective People with HIV (PWH) are more likely to experience problematic emotions and are at increased risk for frailty. In the general population, frailty is broadly associated with worse social–emotional functioning. However, the extent of this dysfunction has largely been isolated to depression and these relationships have yet to be examined among PWH. Thus, this study examined associations between frailty and summary factor scores developed from the National Institutes of Health Toolbox Emotion Battery (NIH-TB-EB) among PWH. Method Participants were 320 PWH (mean age = 52.3, SD = 12.7). Three previously validated composite scores from the NIH-TB-EB were used to assess social–emotional functioning: negative affect, social satisfaction, and psychological well-being. Using the Fried Phenotype, the sample was dichotomized into non-frail (n = 155) and prefrail/frail (n = 165) groups. Multiple regression was used to examine the association between frailty and social–emotional functioning. Covariates included age, estimated duration of HIV infection, antiretroviral therapy (ART) status, and antidepressant medication count. Results Being prefrail/frail was associated with increased negative affect (B = 0.26, p Conclusions Pre-frail/frail PWH have worse social–emotional functioning, above and beyond age, duration of HIV disease, ART status, and antidepressant use. This suggests both frailty and poor social–emotional functioning may be important targets to screen and treat in order to improve prognosis and quality of life for PWH.