509: Ebstein-Barr and ParvoB19 Viruses Are Risk Factors for Late Onset Microvasculopathy after Heart Transplantation

performed for failed Fontan physiology.The median age at the time of the Fontan operation was 4.3 yrs and at transplantation was 11.1 yrs. The primary indications for transplant were ventricular dysfunction, plastic bronchitis, protein losing enteropathy. There were no procedural deaths. There were 3 patients (12%) that required postoperative mechanical support for early graft dysfunction. The median posttransplant ICU stay was 13.7 days. There were 2 hospital deaths (8%), both from acute graft dysfunction. Four patients (16%) died later at a mean post-transplant interval of 58 months. The 19 surviving patients have a mean follow up of 45.5 months. Overall survival for this group was 88%, 80%, and 68% at 1, 5 and 10 yrs post transplant and that compared favorably with those transplanted for cardiomyopathy. This survival was better than for those transplanted for non-Fontan CHD and this difference in survival was significant (p 0.006, log-rank test). Conclusions: Transplantation is a reasonable option for patients with a failing Fontan circulation. While the early post transplant course can be challenging the long term outcome is good and comparable to patients transplanted for cardiomyopathy.