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Advances in solid-state NMR of membrane proteins
- Source :
- Molecular Physics. 114:3598-3609
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- Solid-state nuclear magnetic resonance (SSNMR) is an NMR spectroscopy applied to condensed-phase systems, including membrane proteins. Membrane protein fold and function are dependent upon interactions with surrounding bilayer components. Structural and functional analyses are thus challenging, and new approaches are needed to better characterise these systems. SSNMR is uniquely suited to the examination of membrane proteins in native environments, and has the capabilities to elucidate complex protein mechanisms and structures. Notable research implementing SSNMR is aimed at developing new strategies and technology to efficiently target membrane proteins within synthetic and biological membranes. Significant advances have been made: observation of protein function in native environments, emergence of in situ methods to examine integral proteins within natural membranes, sensitivity enhancement techniques and cutting-edge structure determination methods. We present how these advances are applied to...
- Subjects :
- 0301 basic medicine
Chemistry
Bilayer
Biophysics
Biological membrane
Nuclear magnetic resonance spectroscopy
010402 general chemistry
Condensed Matter Physics
01 natural sciences
0104 chemical sciences
03 medical and health sciences
030104 developmental biology
Membrane
Structural biology
Solid-state nuclear magnetic resonance
Membrane protein
Magic angle spinning
Physical and Theoretical Chemistry
Molecular Biology
Subjects
Details
- ISSN :
- 13623028 and 00268976
- Volume :
- 114
- Database :
- OpenAIRE
- Journal :
- Molecular Physics
- Accession number :
- edsair.doi...........98981659c04d33589eca63f9683dd687
- Full Text :
- https://doi.org/10.1080/00268976.2016.1252470