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Ischemic Postconditioning After Routine Thrombus Aspiration During Primary Percutaneous Coronary Intervention: Rationale and Design of the POstconditioning Rotterdam Trial
- Source :
- Catheterization and Cardiovascular Interventions. 88:508-514
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Background Whether ischemic postconditioning (IPOC) immediately after routine thrombus aspiration (TA) reduces infarct size (IS) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) has not been established. Study design The POstconditioning Rotterdam Trial (PORT) is a dual-center, prospective, open-label, randomized trial with blinded endpoint evaluation enrolling 72 subjects with first-time STEMI, and an occluded infarct-related artery (IRA) without collaterals undergoing PPCI. Subjects are randomized 1:1 to a strategy of IPOC immediately after TA followed by stenting of the IRA or to conventional percutaneous coronary intervention (PCI), including TA followed by stenting of the IRA (controls). Cardiac magnetic resonance imaging (MRI) is performed at 3–5 days after STEMI and at 3 months. The primary endpoint is IS at 3 months measured by delayed enhancement MRI. Other secondary endpoints include MRI-derived microvascular obstruction (MVO), left ventricular ejection fraction, myocardial salvage index, enzymatic IS, ST-segment resolution, myocardial blush grade, microcirculatory resistance, inflammation markers, and clinical events through 3-month follow-up. Conclusions PORT is testing the hypothesis that adding IPOC (against lethal reperfusion injury) to TA (against distal embolization and MVO) is cardioprotective and reduces ultimate IS in STEMI patients undergoing PPCI (Dutch Trial Register identifier: NTR4040). © 2015 Wiley Periodicals, Inc.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
030204 cardiovascular system & hematology
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Cardiac magnetic resonance imaging
Internal medicine
medicine
Clinical endpoint
Radiology, Nuclear Medicine and imaging
cardiovascular diseases
030212 general & internal medicine
Myocardial infarction
Ejection fraction
medicine.diagnostic_test
business.industry
Percutaneous coronary intervention
General Medicine
medicine.disease
Conventional PCI
Cardiology
Cardiology and Cardiovascular Medicine
business
Reperfusion injury
Subjects
Details
- ISSN :
- 15221946
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Catheterization and Cardiovascular Interventions
- Accession number :
- edsair.doi...........98cd1dd897b8ff7baee78fddbfba1f20