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ChemInform Abstract: A Metal-Free Diverse Synthesis of Difluoromethylthioethers and Difluorobis(arylthio)methanes from RSX (X = SR, Cl, SO2Ph) and TMSCF2H

Authors :
Cheng-Pan Zhang
Lei Zhu
Jia-Bin Han
Su-Hong Ye
Hua-Li Qin
Source :
ChemInform. 47
Publication Year :
2016
Publisher :
Wiley, 2016.

Abstract

Construction of difluoromethylthioethers (2) and difluorobis(arylthio)methanes (3) from RSX (X = SR, Cl, SO2Ph) and TMSCF2H in the absence of transition metals has been explored. The reaction is dramatically influenced by the nature of the base and the molar ratio of the reactants. Reactions between RSX and TMSCF2H in the presence of CsF provided 2 in good yields, whereas the reaction of RSX with TMSCF2H in the presence of t-BuOK afforded 3 in good yields. These protocols allow for convenient and efficient access to both difluoromethylthioethers and difluorobis(arylthio)methanes.

Details

ISSN :
09317597
Volume :
47
Database :
OpenAIRE
Journal :
ChemInform
Accession number :
edsair.doi...........99b9441713153a0c0686f1e3ce09912c