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Acoustic fingerprints of photoacoustic contrast agents for molecular imaging

Authors :
Michael A. McDonald
Michael Burcher
Ladislav Jankovic
King C.P. Li
Khalid Shahzad
Source :
Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics.
Publication Year :
2007
Publisher :
SPIE, 2007.

Abstract

Protein nanospheres capable of frequency controlled oscillation in response to laser stimulation are presented as contrast agents for photoacoustic imaging. Incident laser energy absorbed by dye-labeled protein nanospheres causes thermoelastically generated sound production. Plotted A-line graphs reveal a distinctive morphology and greater than 2 orders of magnitude increase in signal amplitude subsequent to converting labeled proteins into nanospheres. Evidence of nonlinearity and enhancement of ultrasound backscatter indicate a potential use in contrast-enhanced harmonic imaging. Photoacoustic and ultrasound imaging of protein nanospheres in phantom vessels show enhanced contrast at low concentration and clear delineation of the phantom vessel wall.

Details

ISSN :
0277786X
Database :
OpenAIRE
Journal :
Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Accession number :
edsair.doi...........9b911c44e4431d0b2bf195ca518ee0c3