Functional imaging predictors of cognitive and sensorimotor impairment in multiple sclerosis

The aim of this study is to determine whether multiple sclerosis (MS) is associated with changes in global degree rank order disruption index (kD), a functional connectivity-based measure representing the overall distribution of nodal degree centrality, and its relationship between the clinical presentation of MS (global disability, cognitive and motor performance). The performance of kD will be assessed in comparison to established magnetic resonance imaging (MRI) biomarkers in MS (regional degree centrality, structural MRI with volumetry, diffusion-weighted imaging [DWI], lesion mapping) in order to assess the potential clinical utility of kD. To this end, a pre-existing dataset of 64 people with MS and 65 healthy control subjects will be evaluated in this secondary analysis.