Back to Search
Start Over
Skin lipid organization, composition and barrier function
- Source :
- International Journal of Cosmetic Science. 30:388-388
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- Citation: IFSCC Magazine, 10 (2007) (4) 297–307 The primary function of the skin is to act as a barrier against unwanted influences from the environment and to protect the body from water loss. The barrier function of the skin is located in the superficial layer of the skin, the stratum corneum. The stratum corneum consists of dead cells filled with keratin and water, the corneocytes, embedded in lipid regions. As the lipid regions are the only continuous structure in the stratum corneum, they are considered to be very important for the skin barrier function. The main lipid classes are ceramides, cholesterol and free fatty acids. In this paper the lipid organization in human stratum corneum is reviewed. In addition, the role the various lipid classes play in lipid organization is discussed using mixtures prepared from either native human ceramides or synthetic ceramides. Finally, a model is described which allows study of the relation between lipid composition, organization and barrier function. This model is referred to as the stratum corneum substitute. Keywords: ceramides, FTIR, lipid organization, stratum corneum, X-ray diffraction
- Subjects :
- chemistry.chemical_classification
Aging
Corneocyte
integumentary system
Cholesterol
Pharmaceutical Science
Dermatology
chemistry.chemical_compound
Colloid and Surface Chemistry
medicine.anatomical_structure
chemistry
Biochemistry
Chemistry (miscellaneous)
Drug Discovery
Keratin
Biophysics
Stratum corneum
medicine
lipids (amino acids, peptides, and proteins)
Composition (visual arts)
Skin lipid
Barrier function
Skin barrier function
Subjects
Details
- ISSN :
- 14682494 and 01425463
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- International Journal of Cosmetic Science
- Accession number :
- edsair.doi...........9c7536153ab2dc79c1c3fe8dc346b31e
- Full Text :
- https://doi.org/10.1111/j.1468-2494.2008.00430_1.x