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Bound Water Molecules at the Interface between the HIV-1 Protease and a Potent Inhibitor, KNI-272, Determined by NMR

Authors :
Stephen J. Stahl
Paul T. Wingfield
Darón I. Freedberg
T. Narayana Bhat
and John W. Erickson
Dennis A. Torchia
Yun-Xing Wang
Yoshiaki Kiso
Joshua D. Kaufman
Source :
Journal of the American Chemical Society. 118:12287-12290
Publication Year :
1996
Publisher :
American Chemical Society (ACS), 1996.

Abstract

KNI-272 is a peptidomimetic transition state analog inhibitor, having very high specificity and binding affinity for the HIV-1 protease. In order to understand the interactions that enhance drug bi...

Details

ISSN :
15205126 and 00027863
Volume :
118
Database :
OpenAIRE
Journal :
Journal of the American Chemical Society
Accession number :
edsair.doi...........9e3e3e422bbab669cc240514766cb79f
Full Text :
https://doi.org/10.1021/ja962612i