Synthesis of the first chiral PNA monomer labelled with a Fischer-type carbene complex

Authors :: Michèle Salmain
Dario Perdicchia
Emanuela Licandro
Clelia Giannini
Barbara Vandoni
Stefano Maiorana
Clara Baldoli
Source :: Journal of Molecular Catalysis A: Chemical. :165-175
Publication Year :: 2003
Publisher :: Elsevier BV, 2003.
Abstract: The synthesis, through a cross-metathesis reaction, of the first chiral peptide nucleic acid (PNA) monomer labelled with a Fischer-type carbene complex of chromium is reported. IR analysis of the new bioconjugate shows that the Cr(CO) 4 moiety represents a suitable spectroscopic probe for diagnostic purposes.

Subjects :: Bioconjugation
Peptide nucleic acid
Stereochemistry
Process Chemistry and Technology
Metathesis
Chemical synthesis
Catalysis
chemistry.chemical_compound
Monomer
chemistry
Moiety
Physical and Theoretical Chemistry
Carbene

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