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ChemInform Abstract: Enantiocomplementary Synthesis of Functionalized Cycloalkenol Building Blocks Using Lipase
- Source :
- ChemInform. 23
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Racemic 2-carbethoxy-2-cyclopenten-1-ol [(±)- 3a ] and racemic 2-carbethoxy-2-cyclohexen-1-ol [(±)- 3b ] afforded the corresponding ( R -acetates [( R )- 4a and ( R )- 4b ] leaving the corresponding ( S )-alcohols [( S )- 3a and ( S )- 3b ] unchanged upon treatment with vinyl acetate in tert -butyl methyl ether in the presence of lipase PS, respectively, while the racemic acetates [(±)- 4a and (±)- 4b ], derived from racemic precursors, (±)- 3a and (±)- 3b , on suspension with lipase in a phosphate buffer solution afforded the corresponding ( R )-alcohols [( R )- 3a and ( R )- 3b ] leaving the corresponding ( S )-acetates [( S )- 4a and ( S )- 4b ] unchanged, respectively.
Details
- ISSN :
- 09317597
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........9f28da3ad5b8bf5f97cb3f982714258e
- Full Text :
- https://doi.org/10.1002/chin.199246065