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Impact of obesity and overweight in the prognosis of women diagnosed with non metastatic breast cancer in a Mexican cohort

Impact of obesity and overweight in the prognosis of women diagnosed with non metastatic breast cancer in a Mexican cohort

Authors :
Martin Granados-Garcia
Gisell Anaid Lara
Itzel Anahi Martinez
Alberto Alvarado Miranda
Daniela Olvera-Caraza
Fernando Lara Medina
Jaime de la Garza
Abelardo Meneses
Alejandro Mohar
Jose Luis Aguilar
Oscar Arrieta
Cynthia Villarreal-Garza
A. Gómez
Source :
Journal of Clinical Oncology. 30:1607-1607
Publication Year :
2012
Publisher :
American Society of Clinical Oncology (ASCO), 2012.

Abstract

1607 Background: Mexico positions right up at the top with U.S. in worldwide rankings of the most obese countries. In addition, breast cancer (BrCa) is the main type of cancer among women in this country. Studies have shown inconsistent results regarding obesity as a prognostic factor for worse outcome. Methods: Our aim is to identify if overweight and obesity confer poor prognosis in non-metastasic BrCa patients (pts). We identified 1799 Hispanic women with newly diagnosed BrCa who attended the National Cancer Institute in Mexico from 2004-2008 and compared clinical and pathological features and overall survival (OS) between pts with a body mass index (BMI) > or ≤ than 25. Results: The median age at diagnosis was 51 years. A BMI>25 was found in 71% of pts. Postmenopausal women comprised 52%, and had a greater proportion of cases with a BMI>25 than premenopausal pts (75% vs. 67%, p25 presented with more advanced TNM stages and nodal involvement than their counterparts (73% vs. 67%, p=0.005 and 76% vs. 71%, p=0.017; respectively). Overall prevalence of hormone-receptor (HR), triple-negative (TN) and HER2 positive disease was 62%, 23%, and 27%, respectively. Differences according to receptor status between pre and postmenopausal pts and BMI are shown in table. There was no difference in disease-free survival and OS according to overweight and obesity in the overall population, but when menopausal status was considered, premenopausal pts with BMI>25 had a worse OS compared to pts with BMI

Details

ISSN :
15277755 and 0732183X
Volume :
30
Database :
OpenAIRE
Journal :
Journal of Clinical Oncology
Accession number :
edsair.doi...........9f67453e011af78e9cc310f5f386a759
Full Text :
https://doi.org/10.1200/jco.2012.30.15_suppl.1607