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Synthesis and actin-depolymerizing activity of mycalolide analogs

Authors :
Akira Sakakura
Hideo Kigoshi
Saori Miya
Tomohisa Handa
Takeshi Kuroda
Kiyotake Suenaga
K. Kanematsu
Source :
Tetrahedron Letters. 45:5383-5386
Publication Year :
2004
Publisher :
Elsevier BV, 2004.

Abstract

Mycalolide analog 4, consisting only of the side chain of mycalolide B (2), was stereoselectively synthesized and was found to have strong actin-depolymerizing activity.

Subjects

Subjects :
Stereochemistry
Chemistry
Organic Chemistry
Drug Discovery
Mycalolide B
Side chain
Actin depolymerizing activity
Biochemistry

Details

ISSN :
00404039
Volume :
45
Database :
OpenAIRE
Journal :
Tetrahedron Letters
Accession number :
edsair.doi...........9fa7558ebe137bb3cefffe1e60b303d1
Full Text :
https://doi.org/10.1016/j.tetlet.2004.05.078
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