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A phase I study of palbociclib (PALBO) plus everolimus (EVE) and exemestane (EXE) in hormone-receptor positive (HR+)/HER2- metastatic breast cancer (MBC) after progression on a CDK4/6 inhibitor (CDK4/6i): safety, tolerability and pharmacokinetic (PK) analysis

Authors :
William T. Barry
Rebecca Rees
Eric P. Winer
Arlindo R. Ferreira
Sara M. Tolaney
Romualdo Barroso-Sousa
Hao Guo
Nikhil Wagle
Source :
Journal of Clinical Oncology. 36:1068-1068
Publication Year :
2018
Publisher :
American Society of Clinical Oncology (ASCO), 2018.

Abstract

1068Background: Although adding a CDK4/6i to endocrine therapy (ET) has proved to prolong progression-free survival in patients (pts) with HR+/HER2- MBC, it is unclear if continuing a CDK4/6i, toge...

Details

ISSN :
15277755 and 0732183X
Volume :
36
Database :
OpenAIRE
Journal :
Journal of Clinical Oncology
Accession number :
edsair.doi...........9ffe011e4eccf59d7d7a10d2dc33f1d1