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A phase I study of palbociclib (PALBO) plus everolimus (EVE) and exemestane (EXE) in hormone-receptor positive (HR+)/HER2- metastatic breast cancer (MBC) after progression on a CDK4/6 inhibitor (CDK4/6i): safety, tolerability and pharmacokinetic (PK) analysis
- Source :
- Journal of Clinical Oncology. 36:1068-1068
- Publication Year :
- 2018
- Publisher :
- American Society of Clinical Oncology (ASCO), 2018.
-
Abstract
- 1068Background: Although adding a CDK4/6i to endocrine therapy (ET) has proved to prolong progression-free survival in patients (pts) with HR+/HER2- MBC, it is unclear if continuing a CDK4/6i, toge...
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
endocrine system diseases
Palbociclib
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pharmacokinetics
Exemestane
Internal medicine
medicine
skin and connective tissue diseases
neoplasms
Everolimus
integumentary system
business.industry
Safety tolerability
medicine.disease
Metastatic breast cancer
Phase i study
030104 developmental biology
chemistry
Hormone receptor
030220 oncology & carcinogenesis
biological phenomena, cell phenomena, and immunity
business
medicine.drug
Subjects
Details
- ISSN :
- 15277755 and 0732183X
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Oncology
- Accession number :
- edsair.doi...........9ffe011e4eccf59d7d7a10d2dc33f1d1