Efficacy of pelvic floor muscle training combined with intravaginal estriol in the treatment of pelvic floor dysfunction in menopausal women: A protocol of randomized controlled trial

Background: Female pelvic floor dysfunction (PFD) is one of the common chronic diseases affecting the physical and mental health of women, which has attracted great attention in the field of gynecology. Pelvic floor muscle training is a commonly used conservative therapy, but it emphasizes the compliance of patients and the treatment cycle is long. There is clear evidence of estradiol receptors (ER) in women's lower urinary tract and reproductive tract, and hormone replacement therapy (HRT) has advantages in the treatment of pelvic floor disorders such as urinary incontinence (UI) and pelvic organ prolapse (POP).There are few studies on the combined treatment of pelvic floor dysfunction in menopausal women, and its safety and effectiveness are also controversial. Methods: We designed a prospective randomized controlled trial. Postmenopausal women with pelvic floor disorders will be randomly assigned in a 1:1 ratio to pelvic floor muscle training combined with intravaginal estriol (observation group) or pelvic floor training (control group).Outcome indexes included pelvic organ prolapse degree, pelvic floor muscle strength score, urinary incontinence efficacy evaluation and adverse reactions. Finally, the research data will be statistically analyzed by SPSS.16. Conclusions: This study will evaluate the efficacy and safety of pelvic floor muscle training combined with intravaginal estriol in the treatment of pelvic floor dysfunction in postmenopausal women, and provide a clinical basis for this combination regimen in the treatment of pelvic floor dysfunction in postmenopausal women.