Interaction of Chlorpromazine with Phospholipid Membranes: A Monolayer and a Microelectrophoresis Approach

Chlorpromazine penetration into the lipid core of the membrane was demonstrated through measurements on lipid monolayers (surface pressure and surface potential). The surface pressure measurements allow us to calculate the intrinsic binding constant (partition coefficient) for the lipid−Chlorpromazine interaction. This latter value is in correct agreement with the obtained results by electrophoretic mobilities measurements on liposomes.