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Perineural invasion affects prognosis of patients undergoing colorectal cancer surgery: a propensity score matching analysis

Authors :
Le Qin
Yixin Heng
Shenghe Deng
Junnan Gu
Fuwei Mao
Yifan Xue
Zhenxing Jiang
Jun Wang
Denglong Cheng
Ke Wu
Yinghao Cao
Kailin Cai
Source :
BMC Cancer. 23
Publication Year :
2023
Publisher :
Springer Science and Business Media LLC, 2023.

Abstract

Background Tumour perineural invasion (PNI) is a predictor of poor prognosis, but its effect on the prognosis of patients with colorectal cancer (CRC) has not yet been elucidated. Methods This retrospective study used propensity score matching (PSM). The clinical case data of 1470 patients with surgically treated stage I–IV CRC at Wuhan Union Hospital were collected. PSM was used to analyse and compare the clinicopathological characteristics, perioperative outcomes, and long-term prognostic outcomes of the PNI(+) and PNI(-) groups. The factors influencing prognosis were screened using Cox univariate and multivariate analyses. Results After PSM, 548 patients were included in the study (n = 274 in each group). Multifactorial analysis showed that neurological invasion was an independent prognostic factor affecting patients’ OS and DFS (hazard ratio [HR], 1.881; 95% confidence interval [CI], 1.35–2.62; P = 0.0001; HR, 1.809; 95% CI, 1.353–2.419; P Conclusions PNI significantly affects the long-term survival and prognosis of patients with CRC undergoing surgery and is an independent risk factor for OS and DFS in patients with CRC undergoing surgery. Postoperative chemotherapy significantly improved the OS of PNI(+) patients.

Subjects

Subjects :
Cancer Research
Oncology
Genetics

Details

ISSN :
14712407
Volume :
23
Database :
OpenAIRE
Journal :
BMC Cancer
Accession number :
edsair.doi...........a07f7434e618173f2332663664dec359