Development of a novel nano-sized carrier system for aeroseol drug delivery (EGE University translational pulmonology research group)

Aim: Formoterol, N-[2-hydroxy-5-(1-hydroxy-2-(4-methoxyphenyl)-1-methylethyl)amino ethyl] is a bronchodilator used in the treatment of obstructive airways diseases.With this preliminary study,we aimed to develop an effective interaction between formoterol and specifically designed nanoparticle based polymeric structures for it under laboratory conditions.This effort relates to developing a new generation medicinal aerosol formulations with nanocarriers in our following studies. Method: Considering abundance of structural rings of formoterol, we chose tryptophan as one of the well-known hydrophobic polymers. p(HEMA) (2-hydroxyethyl methacrylate) nanoparticles were prepared by surfactant free emulsion polymerization and then grafted with L-Tryptophan according to the procedure [1]. Results: L-Tryptophan graft p(HEMA)nanocarriers were characterized by SEM,FTIR,Zeta Sizer.System parameters such as medium pH,adsorption time,adsorption capacity,initial concentration of formoterol-fumarate were optimized. After the optimization of these parameters, formoterol-fumarate releases studying were carried out in different medium pH and drug release kinetic models were also determined. Conclusion: As a result of our initial laboratory experiments,we observed that there were intense hydrophobic interactions between Graft-Trp-p(HEMA) nanocarriers and formoterol.Preliminary findings of this ongoing study look promising. Formoterol and specifically designed Graft-Trp-p(HEMA) nanocarriers have got interaction on laboratory conditions, thus create a highly bioavailable formulation in the future could be possible.Yet the final optimization works still continue.