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Augmentation of Cystic Fibrosis Transmembrane Conductance Regulator Function in Human Bronchial Epithelial Cells via SLC6A14-Dependent Amino Acid Uptake. Implications for Treatment of Cystic Fibrosis
- Source :
- American Journal of Respiratory Cell and Molecular Biology. 61:755-764
- Publication Year :
- 2019
- Publisher :
- American Thoracic Society, 2019.
-
Abstract
- Rationale: SLC6A14 mediated L-arginine transport has been shown to augment the residual anion channel activity of the major mutant, F508del-CFTR, in the murine gastrointestinal tract. It is not yet...
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Gastrointestinal tract
biology
Chemistry
Clinical Biochemistry
Amino acid uptake
Mutant
Cell Biology
Anion channel activity
medicine.disease
Cystic fibrosis
Cystic fibrosis transmembrane conductance regulator
Cell biology
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
030228 respiratory system
Nitric Oxide Pathway
medicine
biology.protein
Molecular Biology
Function (biology)
Subjects
Details
- ISSN :
- 15354989 and 10441549
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- American Journal of Respiratory Cell and Molecular Biology
- Accession number :
- edsair.doi...........a21ee361bbd345affe3ac0e1dcf3fab0
- Full Text :
- https://doi.org/10.1165/rcmb.2019-0094oc