Pathological Function and Clinical Significance of Microrna- 10b in Cancer

Micro RNAs, the endogenous non-coding small RNAs are found involved in cancer pathogenesis. Identification of the miRNA signature in cancer and understanding the underlined regulatory mechanism provide information for clinical decision. Increasing evidences show that miR-10b plays important role in cancer progression and metastasis, thus it may be a therapeutic target for cancer control. Moreover, the alternations of miR-10b expression in malignant diseases provide great potential to use this molecule as a cancer biomarker for early detection, disease assessment or therapeutic monitoring. In this article, we review current knowledge about the cellular function of miR-10b, and discuss its clinical significance and potential application in cancer.