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Feasibility of dose reduction for [18F]FDG-PET/MR imaging of patients with non-lesional epilepsy
- Source :
- Nuklearmedizin - NuclearMedicine. 62:200-213
- Publication Year :
- 2023
- Publisher :
- Georg Thieme Verlag KG, 2023.
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Abstract
- The aim of the study was to evaluate the effect of reduced injected [18F]FDG activity levels on the quantitative and diagnostic accuracy of PET images of patients with non-lesional epilepsy (NLE).Nine healthy volunteers and nine patients with NLE underwent 60-min dynamic list-mode (LM) scans on a fully-integrated PET/MRI system. Injected FDG activity levels were reduced virtually by randomly removing counts from the last 10-min of the LM data, so as to simulate the following activity levels: 50 %, 35 %, 20 %, and 10 % of the original activity. Four image reconstructions were evaluated: standard OSEM, OSEM with resolution recovery (PSF), the A-MAP, and the Asymmetrical Bowsher (AsymBowsher) algorithms. For the A-MAP algorithms, two weights were selected (low and high). Image contrast and noise levels were evaluated for all subjects while the lesion-to-background ratio (L/B) was only evaluated for patients. Patient images were scored by a Nuclear Medicine physician on a 5-point scale to assess clinical impression associated with the various reconstruction algorithms.The image contrast and L/B ratio characterizing all four reconstruction algorithms were similar, except for reconstructions based on only 10 % of total counts. Based on clinical impression, images with diagnostic quality can be achieved with as low as 35 % of the standard injected activity. The selection of algorithms utilizing an anatomical prior did not provide a significant advantage for clinical readings, despite a small improvement in L/B (In patients with NLE who are undergoing [18F]FDG-PET/MR imaging, the injected [18F]FDG activity can be reduced to 35 % of the original dose levels without compromising.
- Subjects :
- Radiology, Nuclear Medicine and imaging
General Medicine
Subjects
Details
- ISSN :
- 25676407 and 00295566
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Nuklearmedizin - NuclearMedicine
- Accession number :
- edsair.doi...........a2fc9f1c89046c261de8a794d326182b
- Full Text :
- https://doi.org/10.1055/a-2015-7785