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Feasibility of dose reduction for [18F]FDG-PET/MR imaging of patients with non-lesional epilepsy

Authors :
Hunor Kertész
Tatjana Traub-Weidinger
Jacobo Cal-Gonzalez
Ivo Rausch
Otto Muzik
Lalith Kumar Shyiam Sundar
Thomas Beyer
Source :
Nuklearmedizin - NuclearMedicine. 62:200-213
Publication Year :
2023
Publisher :
Georg Thieme Verlag KG, 2023.

Abstract

The aim of the study was to evaluate the effect of reduced injected [18F]FDG activity levels on the quantitative and diagnostic accuracy of PET images of patients with non-lesional epilepsy (NLE).Nine healthy volunteers and nine patients with NLE underwent 60-min dynamic list-mode (LM) scans on a fully-integrated PET/MRI system. Injected FDG activity levels were reduced virtually by randomly removing counts from the last 10-min of the LM data, so as to simulate the following activity levels: 50 %, 35 %, 20 %, and 10 % of the original activity. Four image reconstructions were evaluated: standard OSEM, OSEM with resolution recovery (PSF), the A-MAP, and the Asymmetrical Bowsher (AsymBowsher) algorithms. For the A-MAP algorithms, two weights were selected (low and high). Image contrast and noise levels were evaluated for all subjects while the lesion-to-background ratio (L/B) was only evaluated for patients. Patient images were scored by a Nuclear Medicine physician on a 5-point scale to assess clinical impression associated with the various reconstruction algorithms.The image contrast and L/B ratio characterizing all four reconstruction algorithms were similar, except for reconstructions based on only 10 % of total counts. Based on clinical impression, images with diagnostic quality can be achieved with as low as 35 % of the standard injected activity. The selection of algorithms utilizing an anatomical prior did not provide a significant advantage for clinical readings, despite a small improvement in L/B (In patients with NLE who are undergoing [18F]FDG-PET/MR imaging, the injected [18F]FDG activity can be reduced to 35 % of the original dose levels without compromising.

Details

ISSN :
25676407 and 00295566
Volume :
62
Database :
OpenAIRE
Journal :
Nuklearmedizin - NuclearMedicine
Accession number :
edsair.doi...........a2fc9f1c89046c261de8a794d326182b
Full Text :
https://doi.org/10.1055/a-2015-7785